Laying the Groundwork for Empirical Research Support for mRNA Vaccines
Purpose
Strengthening the global competitiveness of Korean mRNA vaccines by establishing key infrastructure to enable the domestic development and commercialization of mRNA vaccines, which have grown in importance since COVID-19, at the Microbiology Demonstration Support Center
Project details
Assisting companies by building facilities and equipment for the commercialization of mRNA vaccines
| Major process | Process and related equipment |
|---|---|
| Preparation of template DNA | - Mass production of plasmid DNA using microorganisms ( Major apparatus ) ⦁ Microbial culture: fermenter, centrifuge, CIP/SIP system, etc. ⦁ DNA purification: ultrafiltration, chromatography system and mixing tanks |
| mRNA synthesis and LNP manufacturing | - mRNA synthesis and modification (In vitro transcription) ( Major apparatus ) ⦁ Reactors, mixing tanks, chromatography systems, ultrafiltration, etc. - LNP(lipid Nanoparticle) manufacturing ( Major apparatus ) ⦁ Jet collision mixer, high pressure crusher, mixing tanks, etc. |
| Production of finished products | - Production of finished products ( Major apparatus ) ⦁ Finished product system for vials (washer, tunnel sterilizer, filling system, etc.) ⦁ Finished product system for syringes (syringe filling system, isolator, etc.) |
Expected outcome
Strengthening the competitiveness of the Korean vaccine industry in the global market by accelerating the development and commercialization of mRNA vaccine products through support for domestic companies
Enhancement of mRNA vaccine platform technology to quickly address pandemic situations and furthering the operation of a global vaccination hub
Korea Bio
pharmaceutical
CMO Center
Public CMO for
Microbial-based
Vaccine